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In “Diabetes Mellitus” by Ellenberg, Rifkin, Porte Jr., Sherwin and Baron, Metformin resulted in 2 to 3 kg of weight loss in the first six months of treatment in most studies. Similarly, in “Handbook of Obesity” by George Bray and Claude Bouchard, an overview of a study comparing Metformin with a placebo in 324 subjects with obesity and insulin resistance found that subjects on Metformin lost an additional 1 to 2 kg of weight than the placebo group. Bray and Bouchard also indicate that in a Metformin study consisting of type 2 diabetic subjects, those who took Metformin lost an average of 3.8 kg. Overall, obese and type 2 diabetic patients who take Metformin should expect a 1 to 4 kg decrease in weight.
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