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CYP1B1 variants also have the ability to catalyse the conversion of oestrogen to unhealthy catechol oestrogen, mainly 16 hydroxyestrone (16 OHE2), which can cause genotoxic mutations. Individuals who inherit low activity COMTT variants are also exposed to a greater risk of breast cancer because of an increased accumulation of the unhealthy catechol oestrogen metabolites.
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