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It’s an infectious disease that literally breaks the hearts of thousands of children worldwide, but we know surprisingly little about it, not even its cause.What the infection is? Don’t know. Why some people are more prone to it? Don’t know. And why people react to it and have a lot of damage to the coronary arteries, we don’t really know.And fascinatingly it is increasing with rapid industrialisation. We just don’t know if it’s a virus, or bacteria, or something else. If undetected in childhood, Kawasaki can lead to heart disease later in life.It’s more common than meningococcal disease, and children with Kawasaki disease have very high fevers, up to forty degrees, and the fevers go on for days. So you need to have a fever for four or five days before you can actually make the diagnosis. They often have a bright red rash, red lips, red eyes bloodshot eyes, swollen and painful hands and feet. Ironically it’s the body’s own defence system that does the damage. The disease attacks the coronary arteries that supply blood to the heart muscle by triggering an overreaction of the immune system. Cells of the immune system invade and inflame the artery walls. How to stop the damage? Dampen down the immune response, as quickly as possible.The only proven treatment for Kawasaki disease at the moment is immunoglobulin, which is antibody taken from blood donors, so it’s the sort of clear part of the blood, not the red part of the blood. 2 day diet pills ? Role of metabolic pathways in regulating aromatase in the context of obesity and breast cancer. (2011) Teasing out the role of aromatase in the healthy and diseased testis. Spermatogenesis 1(3):240 249. (2011) Regulation of LKB1 expression by Sex Hormones in Adipocytes. International Journal of Obesity. Aug 30. doi: 10.1038/ijo.2011.172. (2011) LKB1 expression is inhibited by estradiol 17 in MCF 7 J Steroid Biochem Mol Biol 127:439 43. (2011) Promoter specific effects of metformin on aromatase transcript expression. Steroids 76:768 771.