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Janumet is a medication used to manage type 2 diabetes, a condition in which your body is non insulin dependent (your body does not respond to the insulin hormone that regulates your blood sugars). Metformin lessens the amount of sugar your liver produces, while sitaglipin manages your sugar levels postprandially (after eating). You may initially take a combination of 50 mg of sitaglapin and 500 mg of metformin twice daily or as your doctor prescribes, says the National Library of Medicine..